HUPO launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, reanalysis of community shared data, quality assurance and accurate annotation of the genome-encoded proteome. During the past decade, the HPP established collaborations, developed guidelines/metrics, and reanalyzed previously-deposited community uploaded data, resulting in continuous increases in coverage of the human proteome. Celebrating its recent 10th anniversary, the HPP reported a 90.4% complete high-stringency human proteome blueprint. This presentation addresses strategies for making more of the currently invisible human proteome credibly visible. The HPP blueprint highlights how human proteome knowledge is essential for discerning molecular processes, and with other “omics” data playing a key role in our understanding, diagnoses and treatment of human disease.